Do I need to update or reconfigure any settings in BUSY to submit GST R files without errors?

1: You need to make sure that you are using latest release of BUSY as new changes related GST will shown in new release of BUSY if not then you have to update your BUSY setup.
 For update BUSY setup please follow the below steps:
 i: take backup : close company & then go to comapny menu select backup option then select your company & specify the user name & password of a company & then sepcify the backup location & press on ok tab
 ii: After close the company Go to Company menu 
 iii: Click on check BUSY update and then tick on product & stat updates and then 
 iv: Specify location in download path and then click on download updates
 v: Then you have to open that location then you found two setups one is product uodates & 2nd one is stat updates
 vi: we have install both setups one by one press right click on setup & then run as administrator & then click on yes
 vi: click I accept and next and you have install BUSY both setup in which folder BUSY setup already installed 
 vii: did the same for rest setup and the you can open your BUSY
 2: While generating GSTR1 JSON or through any other format kindly check all possible erros tabs which BUSY provide you before generating GSTR1 eRetrun so that you can clear your retruns all possbile errors as in possible errors you have covered almost all the errors of GST Return
 3: Check your hsn code length. make sure that your hsn code lengh entered according to your turnover