Do I need to create username and password on E-Way bill portal before integrating with BUSY? Which portals do you support?How can I get help with generating e-way bills in the software?

You need to create GSP id from E-way bill portal
Part A: To create GSP id and configure in BUSY for E-way Bill configuration please follow the below Steps: 
Step 1: You have to create a GSP id (GST Suvidha Provider), you need to visit the eway bill portal. 
Step 2: Click on regisration option then you have to Click on GSP and then send OTP and verify 
Step 3: Create id with Selecting Webtel Electrosoft Private Limited and Pinnacle Finserv Advisors Private Limited as a GSP Vendor type. 
Step 3: Go to Administration and click on configuration. 
Step 4: Select Features / Options and click on GST / VAT, here you will see a option called E-way Required. 
Step 5: Set Y to turn it on and mention your place and pincode, all required and user restrictions also you can define and then clck on GSP configuration Tab then paste GSP username and password and save the configuration which we create from e-way bill portal 
Step 6: Go back to Administration and click on configuration. 
Step 7: Choose the Voucher Series Configuration option and select the voucher type for which you want to generate e invoice, such as sales, sales return, etc. and select series & then click on voucher configuration then enable generate E-invoice after saving and save. 
Part B: Generate E-way bill in BUSY: 
Step 1: Go to transaction then open the voucher or create a voucher of which you want generate E-way bill 
Step 2: Make sure that the station, pin code, address, and GSTIN of the party are updated in the party master and the item tax category and valid HSN code are specified in the item master. 
Step 3: Afterward, Select Y for E Way Bill required option and also mention station and Pin code in transport window along with transporter or Vehicle number. 
Step 4: After Saving the Invoice, Click on YES to generate E-Way Bill and then select Automatic mode for it. 
Step 5: Then Click on check possible errors tab and rectify the errors if have Step 6: After error rectification , click on view & generate E invoice option 
Step 7: Cross verify the details appear in window and generate E way bill.